|In treating otitis externa in dogs there are many products available. Most contain multiple agents including an antibiotic to kill the offending bacteria, anti-fungal agent for any yeast infection and a steroid to reduce inflammation. Earigant ® SP contains a single antimicrobial agent, chlorine dioxide, in a stabilized complex. The solution is effective against all bacteria and yeast that cause ear infections in dogs and cats. Using Earigant SP eliminates the need to culture the ear in order to determine an appropriate antimicrobial formulation. Other agents in Earigant ® SP are added to assist cleaning the ear, reduce irritation and promote healing.|
Pharmaceutical Inc, Melville, N.Y.
11747 has recently developed a proprietary formulation of
stable chlorine dioxide complex in liquid form that has
been incorporated into its DioxiCare ® line of
veterinary antiseptic products. The product is available
in a 1 oz (30 ml) plastic squeeze bottles with a conical
dropper dispenser. The product is used for cleaning,
irrigating and direct application in the topical
management of otitis. Other ingredients added to the
formulation such as surfactants, glycerin and carbamide
assist in cleaning the ear, reduce irritation and promote
Past formulations have required the mixing of two ingredients to release the active chlorine dioxide component. This new formulation has eliminated this requirement making this single product (SP) more convenient for use in clinical practice.
|Chlorine dioxide (ClO2) is a gas that dissolves readily in water. The molecule is a free radical because of an unpaired electron. This makes the compound particularly active as an oxidizing agent. Unlike chlorine (Cl2), chlorine dioxide is eco-friendly. It does not hydrolyze in water to form hydrochloric acid but remains in solution as a dissolved gas. Chlorine dioxide does not form chlorinated hydrocarbons, which can be carcinogenic. The aqueous solution is non irritating to the skin. Chlorine dioxide as a strong oxidizing agent and a fast acting microbicidal agent effective at low concentrations. It is widely used as a water purifier, disinfectant and as a topical antiseptic agent with a wide spectrum of microbicidal activity against bacteria, yeast, fungi, protozoa, and viruses.|
In Vitro Studies To demonstrate the microbicidal efficacy of chlorine dioxide on common bacteria and yeast isolated from clinical cases, cultures of the organisms were exposed to chlorine dioxide solution . The bacteria included Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli and the yeast organism was Malassezia pachydermatis isolated from a dog with chronic ear infection.
A standardized suspension of each bacteria was prepared and the organism was cultured onto two trypticase soy agar plates. One untreated plate was used as a control, the other was immediately sprayed with the chlorine dioxide complex. Both plates were cultured for 18 hours after which they were inspected for growth of bacterial colonies.
The Malasezzia, yeast organism was isolated cultured directly onto two Sabouraud Dextrose Agar plates. One plate was sprayed with the chlorine dioxide complex solution immediately and again after 24 hours. The second control plate was untreated. The plates were sealed and incubated for a total of 12 days at room temperature then inspected.
The results of this study demonstrated that no growth was observed on any of the chlorine dioxide treated plates on the right side after appropriate incubation period. Abundant growth of bacterial colonies and yeast organisms was noted on the respective control agar plates shown to the left side.
Bacterial organisms tested included Staph. aureus, Pseudomonas aeruginosa and Eschericia coli and the yeast organism was Malassezia pachydermitis..
electron micrographs taken of Pseudomonas
spp and Escherichia coli have also
demonstrated the antimicrobial effects of chlorine
dioxide as a biocide.
Escherichia coli after 1 minute exposure to chlorine dioxide showing similar features of destruction of the cell membrane and internal organelles..
(TEM 43,000 x magnification)
|To clean the ear dispense
several drops into the ear, enough to wet the canal and
gently massage the ear. Leave the solution in for about
30 seconds. The microcidal effect will occur within this
period. Clean out the debris using a cotton swab.
Cleaning can be done on a regular basis such as once a
week to prevent infection especially in those breeds
prone to infection.
To treat and infection follow the steps for cleaning Once the ear is clean and dry add a few more drops to the ear (enough to coat the lining) and allow to dry. Repeat on a twice daily basis until the infection is under control. (usually 5-10 days).
The product can be dispensed with the client with appropriate instructions for use.
Earigant SP can be used in conjunction with systemic medications such as an oral antibiotic or steroids but should not be mixed, at the same time, with other topical medications as it may oxidize the medication being used. Other topicals can be used after a short period (5-10 minutes) of the cleaning or treating of the ear with Earigant ® SP. A topical steroid, for example might be considered if there is intense pruritis associated with hypersensitivity due to the breakdown of the microorganisms.
For more information contact Frontier Pharmaceutical Inc., Melville, NY. (631) 367-3400 or visit www.frontierpharm.info
Veterinarians who wish to try Earigant SP may email Dr. Wilkins at firstname.lastname@example.org to request a free sample.
Please include your name and hospital or clinic address.
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